Can Mounjaro Help You Lose Weight? Know The Science And Facts

Have you heard about Mounjaro? According to the UC Health, it is a new medicine that helps people with type 2 diabetes lose weight. But do you know how it works? Well, it has a special ingredient called Tirzepatide. This ingredient not only helps control diabetes but also helps people lose some weight.

So, let’s break it down. We will talk about how Mounjaro works, how good it is at helping people lose weight, and what doctors have found out about it. We will also talk about why some people might not see much weight loss with mounjaro injection and how long it sticks around in the body.

Now, If you’re thinking about trying Mounjaro, we will give you some tips on how much to take and what side effects to watch out for. And also we will finish up by looking at what the future might hold for Mounjaro as a weight loss treatment. So, whether you’re a doctor, a patient, or just curious, this article has something for everyone!

Understanding Mounjaro And Its Role In Weight Management

It’s essential to comprehend what Mounjaro is and how it functions in order to realize its potential for weight loss completely.

This section will provide a comprehensive overview of Mounjaro, its mechanism of action, and its significance as a GLP-1 receptor agonist

What Is Mounjaro?

Mounjaro (tirzepatide) is an innovative medication used primarily for managing type 2 diabetes, but it has also shown remarkable potential for weight loss. Administered as a once-weekly injection, it is designed to work alongside a healthy diet and exercise regimen to regulate blood sugar levels effectively.

Understanding Tirzepatide – The Active Ingredient

The active ingredient in Mounjaro is tirzepatide, which functions as a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) receptor agonist. This dual action is unique, as most diabetes medications only target GLP-1 receptors.

Clinical studies have demonstrated significant benefits of tirzepatide for both diabetes management and weight loss:

• A 2022 SURMOUNT-1 clinical trial found that participants taking a 15 mg dose of tirzepatide lost an average of 20.9% of their body weight over 72 weeks, compared to just 3.1% in the placebo group (source).
  
• According to the National Library Of Medicine, the SURPASS trials, which assessed tirzepatide’s effects on type 2 diabetes, revealed that it lowered HbA1c levels by up to 2.58%, making it highly effective for blood sugar control (source).

Mounjaro was approved by the FDA in May 2022 for managing blood sugar in adults with type 2 diabetes when combined with lifestyle changes. However, it is not recommended for individuals with type 1 diabetes or those with a history of pancreatitis.

How Mounjaro  Works For Diabetes And Weight Loss?

Mounjaro works by mimicking certain hormones in the body called incretins. These hormones play a key role in controlling blood sugar levels and appetite. By mimicking these hormones, Mounjaro can help reduce appetite and potentially lead to weight loss over time. 

• Increases insulin production: Encourages the pancreas to release more insulin in response to meals, improving blood sugar control.
  
• Reduces sugar production: Suppresses glucose production in the liver, preventing excess sugar from entering the bloodstream.
  
• Slows digestion: Delays stomach emptying, keeping you full longer and reducing overall food intake.
  
• Suppresses appetite: Acts on brain receptors to reduce hunger, aiding in weight management.

Research says that compared to placebo, patients lost up to 22.5% of their body weight in trials, making it one of the most effective weight loss medications to date.

However, weight loss results vary among individuals, and Mounjaro works best when combined with a healthy lifestyle.

If you’re considering Mounjaro for diabetes or weight loss, consult your doctor or endocrinologist to evaluate its suitability for your health condition.

The Significance Of Glp-1 Receptor Agonists

Mounjaro belongs to a group of weight loss medications known as GLP-1 receptor agonists. These weight loss drugs have gained attention for their ability to help with weight loss, making them an exciting option for people struggling with obesity. 

Here’s why GLP-1 receptor agonists like Mounjaro are significant:

• They mimic the action of incretin hormones, which help regulate blood sugar and appetite.
• They can enhance the body’s insulin sensitivity, a common reduction in individuals with obesity.
• By reducing appetite, they can lead to a decrease in calorie intake and potential weight loss.
• Clinical trials have shown promising results for weight loss with GLP-1 receptor agonists.
• They offer an alternative for people who may not be eligible for weight loss surgery.

Understanding these aspects of Mounjaro and GLP-1 receptor agonists can help individuals make informed decisions about their weight management options. It’s important to discuss any questions or concerns with a healthcare provider to determine if Mounjaro is the right choice for you.

Mounjaro Benefits: Why Is It Creating Buzz?

Its dual-action mechanism and remarkable outcomes in weight loss and diabetes control have brought mounjaro (tirzepatide) much attention. Recent clinical studies highlighting its superiority over other GLP-1 receptor agonists have made it a game-changer in medicine.

1. Effective Blood Sugar Control

Mounjaro is FDA-approved for type 2 diabetes and helps lower HbA1c (average blood sugar levels) by up to 2.1%. It encourages insulin production, reduces glucose release from the liver, and delays the need for insulin therapy.

2. Significant Weight Loss

One of the biggest reasons Mounjaro is making headlines is its remarkable impact on weight loss. Clinical trials showed that patients lost up to 20.9% of their body weight in 72 weeks, outperforming other weight-loss medications.

3. Heart Health Benefits

According to an article, Mounjaro may reduce the risk of heart disease by lowering bad cholesterol (LDL), improving blood pressure levels, and enhancing blood vessel function. These benefits can help prevent strokes and heart attacks.

4. Improves Metabolism & Fat Reduction

Mounjaro helps the body burn fat more efficiently while improving insulin sensitivity. It may also reduce belly fat and prevent fat buildup in the liver, which is beneficial for fatty liver disease.

5. Benefits for PCOS & Hormonal Health

According to the National Institutes Of Health, women with Polycystic Ovary Syndrome (PCOS) may benefit from Mounjaro’s ability to regulate blood sugar, manage weight, and reduce inflammation. Since insulin resistance is a major issue in PCOS, Mounjaro’s effects can help improve hormonal balance.

6. Gut Health & Digestive Benefits

Mounjaro slows digestion, which can help with acid reflux, gut hormone function, and controlling cravings. A balanced gut microbiome is essential for long-term metabolic health and weight management.

7. May Reduce Alzheimer’s & Cognitive Decline Risk

Recent research suggests that weight loss drugs like GLP-1 receptor agonists (like Mounjaro) may reduce brain inflammation, improve memory, and lower the risk of neurodegenerative diseases in people with diabetes. Ongoing studies are exploring these potential cognitive benefits.

Side Effects And Risks Of Mounjaro

Mounjaro, like any medication, can cause side effects, some of which are common and others more serious. Here’s an overview:

Common side effects of Mounjaro, affecting 5% or more of patients, may include:

• Nausea
• Diarrhea
• Decreased appetite
• Vomiting
• Constipation
• Dyspepsia (indigestion)
• Abdominal pain

Serious side effects of Mounjaro that require immediate medical attention include:

• Allergic reactions: Symptoms include hives, difficulty breathing, lightheadedness, and swelling of the face, lips, tongue, or throat.
• Pancreatitis: Symptoms include severe upper stomach pain spreading to the back, nausea, and vomiting.

Other serious side effects that require prompt medical attention:

• Severe stomach problems
• Eye side effects or vision changes, like blurry vision
• Signs of a thyroid tumor, such as neck swelling or a lump, difficulty swallowing, hoarse voice, or shortness of breath
• Gallbladder problems, including chalky-colored stools, stomach pain after eating, nausea, heartburn, bloating, and severe upper stomach pain spreading to the back
• Low blood sugar: Symptoms may include headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery
• Kidney problems: Indicated by little or no urination, swelling in the feet or ankles, fatigue, or shortness of breath

Remember, this isn’t an exhaustive list of side effects. If you experience any unusual symptoms while taking Mounjaro, it’s essential to consult your doctor promptly. They can provide medical advice and report any side effects to the FDA for further evaluation.

How Is Mounjaro Used?

Using Mounjaro is quite straightforward. You’ll get it as an injection just below your skin, usually once a week, regardless of meal times.

Here’s a simple guide on how to use it:

• Choose an injection site on your abdomen or the front of your thigh (or a caregiver can do it on the back of your upper arm). Make sure the area is clean and dry, and avoid any damaged or discolored skin.

• Check that the Mounjaro pen is locked.
• Remove the gray base cap and place the bottom of the pen flat against your skin.
• Unlock the pen, then press and hold the purple injection button for about 10 seconds.
• Listen for two clicks – one at the start and one at the end of the injection.
• Dispose of the pen in a sharps disposal container.

These are just the basics. You can find more detailed instructions on the manufacturer’s website or consult your doctor or pharmacist for any questions or concerns you may have about using Mounjaro.

What If You Miss A Dose?

Missed dose within 4 days? Take it as soon as you remember and follow your regular schedule.

Missed dose beyond 4 days? Skip it and wait for your next scheduled dose.

Important: Do not take two doses close together or within 72 hours. Consult your doctor if unsure.

Tip: Use alarms, reminder apps, or a planner to stay on track.

Who Should Avoid Mounjaro Use?

1. For people with Type 1 Diabetes: Mounjaro isn’t effective for type 1 diabetes since it depends on the ability of the body to produce insulin and is only accepted for type 2 diabetes.

2. Those With A History Of Pancreatitis: Mounjaro could raise the possibility of that suffering. For those who have had acute or chronic pancreatitis, this drug should be avoided.

3. People With A Personal Or Family History Of Thyroid Cancer: Mounjaro has a caution for medullary thyroid carcinoma, an unusual form of thyroid cancer. If you or a relative has had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), it should not be used.

4. Pregnant Or Breastfeeding Women: Too few studies exist on Mounjaro’s influence on breastfeeding and pregnancy. Stopping Mounjaro is advised at least two months before trying to conceive.

5. Disorders Related To Digestion:  Since Mounjaro slows digestion, it may worsen conditions like gastroparesis (delayed stomach emptying), severe acid reflux (GERD), or IBD (Crohn’s disease, Ulcerative colitis).

6. Patients With Severe Kidney Or Liver Disease: Especially if you already have kidney disease, Mounjaro can lead to dehydration and renal tension. Your doctor might need to keep you close watch if you suffer from strong liver damage.

7. Individuals Allergic To Tirzepatide: You should not use the drug if you have had an allergic reaction to Mounjaro or one of its components. An allergic response can cause rash, inflammation, trouble breathing, or intense nausea.

8. People using Particular Medications: Mounjaro might interact with insulin or sulfonylureas (which may result in hypoglycemia) and oral medications (since Mounjaro slows down digestion, it could impact how your body absorbs drugs). If you are taking many drugs, always ask a doctor first before starting Mounjaro.

Although not for everybody, Mounjaro is a strong aid in weight management and diabetes. Speak with your doctor to discover better methods if you have any of the above issues. Let me know if you want a comparison with natural options or other weight-loss medicines.

Is Mounjaro Available In India?

Mounjaro (tirzepatide) is a medication developed by Eli Lilly and Company, primarily approved for managing type 2 diabetes. While it has shown potential in weight management, its availability and approval status vary by country.

Approval Status in India – Is It Legal?

As of now, Mounjaro has not been officially approved by Indian regulatory authorities for general medical use. However, patients in India can access Mounjaro through specific channels:

Prescription Requirement: Mounjaro is classified as a prescription medication. Patients need a valid prescription from a qualified healthcare professional to obtain it.

Special Access Programs: Some pharmaceutical networks, like the Indian Pharma Network, facilitate access to Mounjaro under special programs. These programs often require:

• A valid prescription.
• An import permit, if applicable.
• Government-issued identification proof.

It’s essential to consult with a healthcare provider to understand the suitability and legalities of obtaining Mounjaro in India.

Note: The Food and Drug Administration (FDA) has approved Mounjaro to treat type 2 diabetes. In some cases, your doctor may prescribe Mounjaro off-label for weight loss. Off-label drug use occurs when healthcare providers prescribe an FDA-approved drug for a purpose other than its approved indication.

Mounjaro vs. Other Diabetes & Weight Loss Medications

Research presented at the European Association for the Study of Diabetes (EASD) 2023 suggests that Mounjaro (tirzepatide) may be more effective than Ozempic (semaglutide) for both weight loss and blood sugar control in people with type 2 diabetes:

1. Mounjaro vs. Ozempic (Semaglutide)

Mounjaro is more effective in lowering A1C levels and promoting weight loss. Researchers found that people taking Mounjaro were 2.5 times more likely to lose at least 10% of their body weight and 3 times more likely to lose at least 15% in their first year compared to those on Ozempic.

It also works faster due to its dual action on GIP and GLP-1 receptors, making it a stronger option for diabetes and weight loss.

2. Mounjaro vs. Wegovy (Weight Loss Version of Ozempic)

Wegovy, approved specifically for weight loss, helps patients lose 12% of body weight, while Mounjaro has shown weight loss of up to 22% in clinical trials. This makes Mounjaro a more effective option for obesity treatment, especially in those without diabetes.

3. Mounjaro vs. Saxenda (Liraglutide)

Saxenda requires daily injections and results in about 8% weight loss, which is significantly lower than Mounjaro. Since Mounjaro is taken weekly and offers greater weight loss, it is often the preferred choice.

Studies revealed that Mounjaro led to 15% more weight loss than Saxenda over 72 weeks, with participants losing 20% of their body weight on Mounjaro vs. 6.4% on Saxenda.

4. Mounjaro vs. Trulicity (Dulaglutide)

Trulicity is mainly used for diabetes management but is less effective for weight loss. While it helps control blood sugar, it does not provide the same level of appetite suppression and fat reduction as Mounjaro.

5. Mounjaro vs. Other Weight Loss Drugs

Many traditional weight loss medications focus only on suppressing appetite, whereas Mounjaro works on blood sugar regulation, appetite control, and metabolism. This makes it a more comprehensive option for both diabetes and obesity management.

There’s ongoing research to evaluate whether patients need to keep taking Mounjaro to maintain weight loss. This upcoming trial will look at the effectiveness and safety of Mounjaro for maintaining weight loss in overweight or obese adults.

Conclusion

Mounjaro, with its active ingredient tirzepatide, holds promise as both a treatment for type 2 diabetes and a potential aid for weight loss. Its mechanism of action, mimicking incretin hormones and targeting GIP and GLP-1 receptors, offers a multifaceted approach to managing blood sugar levels and appetite. 

Here are the key takeaways:

• What is Mounjaro?: Mounjaro is a once-weekly injectable medication for type 2 diabetes that also promotes significant weight loss. It works best when combined with a healthy diet plan and regular exercise.
  
• How Mounjaro Works: It mimics incretin hormones (GIP & GLP-1) to regulate blood sugar, increase insulin production, and suppress appetite. It also slows digestion, keeping you full for longer and reducing overall calorie intake.
  
• Clinical Studies & Effectiveness: The SURMOUNT-1 trial showed a 20.9% body weight loss with a 15 mg dose over 72 weeks. The SURPASS trials reported a 2.58% HbA1c reduction, proving its effectiveness for diabetes and weight loss.
  
• Benefits of Mounjaro: Mounjaro lowers blood sugar, supports weight loss, improves heart health, and enhances metabolism. It also helps with PCOS, gut health, and may reduce the risk of Alzheimer’s by lowering brain inflammation.
  
• Who Should Avoid Mounjaro?: People with type 1 diabetes, pancreatitis, thyroid cancer history, or severe digestive issues should avoid it. Pregnant women, those with kidney/liver disease, or those taking specific medications should consult a doctor first.
  
• Side Effects of Mounjaro: Common side effects include nausea, diarrhea, constipation, and abdominal pain. Serious risks include pancreatitis, thyroid tumors, severe stomach issues, and kidney problems, requiring medical attention if they occur.
  
• Mounjaro vs. Other Medications: Mounjaro is 2.5 times more effective than Ozempic, causes twice the weight loss compared to Wegovy, and outperforms Saxenda by delivering nearly three times the weight loss results.
  
• Availability in India: Mounjaro is not officially approved in India but may be available through special import programs with a doctor’s prescription. Consultation with a healthcare professional is necessary before use.

As more studies are conducted, Mounjaro’s role in weight management may become clearer, providing additional options for individuals struggling with obesity. 

It’s essential to consult with healthcare providers to explore the suitability of Mounjaro as part of a comprehensive weight management plan.

How A Right Diet Plan Can Help You Lose Weight?

So, Shradha is from Rotak and is a teacher. She was suffering from the extra weight on her body and so, she was desperate to get fit and slim.

The problem during Shradha’s weight loss journey was that she used to get tired very quickly, in short fatigue. She also did not do much physical exercise.
She had also, tried doing a diet before and could not succeed. But after reaching out to Fitelo. She lost 20 kg in 120 days. Moreover, went from XXL to M in size, which is like just Wao!

Hence all you need is the right diet and guidance to motivate you to make things possible.

Shradha’s Weight Loss Transformation: 20 Kg Gone In 120 Days

Frequently Asked Questions

Is Mounjaro Approved For Weight Loss?

Mounjaro is FDA-approved for type 2 diabetes but not officially for weight loss. However, doctors prescribe it off-label for weight management due to its proven effectiveness.

Do You Get Mounjaro In India?

Mounjaro is not officially available in India but may be accessed through special import programs with a doctor’s prescription. Always consult a healthcare provider before use.

Which Is Better, Ozempic Or Mounjaro?

Mounjaro is more effective than Ozempic for both blood sugar control and weight loss. Studies show it leads to nearly twice the weight loss compared to Ozempic.

Can You Lose 20 Pounds In A Month On Mounjaro?

Weight loss varies, but losing 20 pounds in a month is unlikely. Most people lose 5-15% of their body weight over several months with proper diet and exercise.

Contact Us Today

Your search to find the right guidance to be a part of all those fat-to-fit stories ends here. So, contact us today if you are looking for a diet plan with cheat meals. Also, we will discuss how we can help you achieve your weight loss goals.

Disclaimer

This blog post was written to help you make healthy and better food choices. So, be aware and take care. The most important thing to consider is your health before starting a restrictive diet. Always seek advice from a doctor or dietitian before starting, if you have any concerns.

Eat healthy and live healthy. Enjoy a long, happy life.